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Fabrication and nanostructural tuning of a novel GSH-responsive triblock polyprodrug amphiphiles

  • 1.

    Department of Chemistry, Anhui University, Hefei 230601, China

  • 2.

    Department of Chemistry, Huainan Normal University, Huainan 232038, China

  • 3.

    Ministry of Education Key Laboratory of Laser Life Science and Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, 510631, China

Cite this: JUSTC, 2014, 44(11): 893-903
https://doi.org/10.3969/j.issn.0253-2778.2014.11.003
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  • Received Date: June 11, 2014
  • Revised Date: October 16, 2014
  • Published Date: November 29, 2014
    Abstract
  • Based on the feature of tumors reduction-responsive milieu, a novel type of glutathione (GSH)-responsive polyprodrug amphiphiles, PCPTM-b-PEG-b-PCPTM triblock copolymers was fabricated, with CPT loading content higher than 50% (mass fraction). It is found that aqueous self-assembly of PCPTM-b-PEG-b-PCPTM is strongly dependent on common solvent compositions, affording two kinds of distinct nanostructures, staggered lamellae and large compound micelles determined by TEM and SEM analysis with the common solvent to be 1,4-dioxane and DMF, respectively. Further cellular experiments reveal that both staggered lamellae and large compound micelles possess relatively high rates of tumor cellular internalization and effective anticancer performance.
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