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ISSN 0253-2778

CN 34-1054/N

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2022, 52(5): 3-1-3-14.

An empirical Bayes method for genetic association analysis using case-control mother-child pair data .

Figures of the Article

Type-I error rates for the significance tests of $\beta_{mx_1}$ with $\rho=0$ (HWE) or $\rho=0.1$ (HWD), various sample sizes ( $n_1=n_0=150$ , $n_1=n_0=300$ , and $n_1=n_0=1000$ ), and various $\eta$ values ( $0$ through $\log(2.5)$ ). The other parameters were fixed: $\beta_{c}=\text{log}(1.8)$ , $\beta_{m}=\text{log}(1.3)$ , $\beta_{x_1}=\beta_{x_2}=-\text{log}(1.2)$ , $\beta_{cx_1}=\beta_{cx_2}=-\text{log}(1.5)$ , and $\beta_{mx_2}=\text{log}(1.2)$ .
Powers for the significance tests of maternal gene-environment interaction ( $\beta_{mx_1}$ ) with HWE ( $\rho=0$ ), various sample sizes ( $n_1=n_0=150$ , $n_1=n_0=300$ , and $n_1=n_0=1000$ ), and various $\eta$ values ( $0$ , $\log(1.2)$ , and $\log(1.5)$ ). The other parameters were fixed: $\beta_{c}=\text{log}(1.8)$ , $\beta_{m}=\text{log}(1.3)$ , $\beta_{x_1}=\beta_{x_2}=-\text{log}(1.2)$ , $\beta_{cx_1}=\beta_{cx_2}=-\text{log}(1.5)$ , and $\beta_{mx_2}=\text{log}(1.2)$ .
Powers for the significance tests of maternal gene-environment interaction ( $\beta_{mx_1}$ ) with HWD ( $\rho=0.1$ ), various sample sizes ( $n_1=n_0=150$ , $n_1=n_0=300$ , and $n_1=n_0=1000$ ), and various $\eta$ values ( $0$ , $\log(1.2)$ , and $\log(1.5)$ ). The other parameters were fixed: $\beta_{c}=\text{log}(1.8)$ , $\beta_{m}=\text{log}(1.3)$ , $\beta_{x_1}=\beta_{x_2}=-\text{log}(1.2)$ , $\beta_{cx_1}=\beta_{cx_2}=-\text{log}(1.5)$ , and $\beta_{mx_2}=\text{log}(1.2)$ .

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CN 34-1054/N

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