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Toxicity of halloysite nanotubes in liver of mice after oral administration

  • Department of Chemistry, University of Science and Technoogy of China, Hefei 230026, China

Funds:  Supported by the National Natural Science Foundation of China(21171157,20871111,20571069)
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https://doi.org/10.3969/j.issn.0253-2778.2017.12.003
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  • Author Bio:

    WANG Xue, female,born in 1990, Master candidate. Research field: bioinorganic chemistry. E-mail:wx1223@mail.ustc.edu.cn

  • Corresponding author: XU Xiaolong
  • Received Date: 18 April 2017
  • Rev Recd Date: 15 May 2017
  • Publish Date: 30 December 2017
    Abstract

  • Abstract

    Halloysite is widely used in many fields due to its natural hollow nanotubular structure. To assess the liver toxicity of the purified halloysite nanotubes (HNTs) in mice via oral route, purified HNTs were orally administered to mice at 4, 20 and 100 mg/kg BW body weight (BW) every day for 30 d. Oral administration of HNTs stimulates the growth of the mice at low dose (4 mg/kg BW) with no liver toxicity, but inhibits the growth of the mice and induces oxidative stress in the liver at high dose (≥20 mg/kg BW). In addition, oral administration of HNTs at high dose causes Al accumulation in liver, which induces hepatic dysfunction and histopathologic changes.

    Abstract

    Halloysite is widely used in many fields due to its natural hollow nanotubular structure. To assess the liver toxicity of the purified halloysite nanotubes (HNTs) in mice via oral route, purified HNTs were orally administered to mice at 4, 20 and 100 mg/kg BW body weight (BW) every day for 30 d. Oral administration of HNTs stimulates the growth of the mice at low dose (4 mg/kg BW) with no liver toxicity, but inhibits the growth of the mice and induces oxidative stress in the liver at high dose (≥20 mg/kg BW). In addition, oral administration of HNTs at high dose causes Al accumulation in liver, which induces hepatic dysfunction and histopathologic changes.
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    • References(17)
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    ZHANG Y, GAO R, LIU M, et al. Use of modified halloysite nanotubes in the feed reduces the toxic effects of zearalenone on sow reproduction and piglet development[J]. Theriogenology, 2015,83 (5): 932-941.
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    JANI P, HALBERT G W, LANCRIDGE J, et al.Nanoparticle uptake by the rat gastrointestinal mucosa:Quantitation and particle size dependency[J]. Journal of Pharmacy & Pharmacology, 1990, 42 (12): 821-826.
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    [1]
    YUAN P, TAN D, ANNABI-BERGAYA F. Properties and applications of halloysite nanotubes: Recent research advances and future prospects[J]. Applied Clay Science, 2015,112-113: 75-93.
    [2]
    ABDULLAYEV E, LVOV Y. Halloysite clay nanotubes as a ceramic “skeleton” for functional biopolymer composites with sustained drug release[J]. Journal of Materials Chemistry B, 2013,1 (23): 2894-2903.
    [3]
    ZHANG Y, TANG A, YANG H, et al. Applications and interfaces of halloysite nanocomposites[J]. Applied Clay Science, 2015,119:8-17.
    [4]
    VERGARO V, ABDULLAYEV E, LVOV Y M, et al. Cytocompatibility and uptake of halloysite clay nanotubes[J]. Biomacromolecules, 2010,11(3): 820-826.
    [5]
    LAI X, AGARWAL M, LVOV Y M, et al. Proteomic profiling of halloysite clay nanotube exposure in intestinal cell co-culture[J]. Journal of Applied Toxicology,2013, 33 (11): 1316-1329.
    [6]
    ZHANG Y, CHEN Y, ZHANG H,et al.Potent antibacterial activity of a novel silver nanoparticle-halloysite nanotube nanocomposite powder[J].Journal of Inorganic Biochemistry, 2013,118 (1): 59-64.
    [7]
    FAKHRULLINA G I, AKHATOVA F S, LVOV Y M, et al.Toxicity of halloysite clay nanotubes in vivo: A Caenorhabditis elegans study[J]. Environmental Science Nano, 2015, 2 (1): 54-59.
    [8]
    RONG R, XU X L, ZHU S S, et al. Facile preparation of homogeneous and length controllable halloysite nanotubes by ultrasonic scission and uniform viscosity centrifugation[J].Chemical Engineering Journal, 2016, 291: 20-29
    [9]
    MEENA R, PAULRAJ R. Oxidative stress mediated cytotoxicity of TiO2 nano anatase in liver and kidney of Wistar rat[J]. Toxicological & Environmental Chemistry, 2012,94 (1): 146-163.
    [10]
    XU B, XU Z F, DENG Y, et al.Protective effects of Chlorpromazine and Verapamil against cadmium-induced kidney damage in vivo[J]. Experimental & Toxicologic Pathology, 2010, 62 (1): 27-34.
    [11]
    DOBBIE J W, SMITH M J B. Urinary and serum silicon in normal and uremic individuals[J]. iba Found Symp, 1986, 121: 194-213.
    [12]
    ZHANG Y, GAO R, LIU M, et al. Use of modified halloysite nanotubes in the feed reduces the toxic effects of zearalenone on sow reproduction and piglet development[J]. Theriogenology, 2015,83 (5): 932-941.
    [13]
    WANG J, ZHOU G, CHEN C, et al. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration[J]. Toxicology Letters, 2007, 168 (2): 176-185.
    [14]
    JANI P, HALBERT G W, LANCRIDGE J, et al.Nanoparticle uptake by the rat gastrointestinal mucosa:Quantitation and particle size dependency[J]. Journal of Pharmacy & Pharmacology, 1990, 42 (12): 821-826.
    [15]
    MANKE A, WANG L, ROJANASAKUL Y. Mechanisms of nanoparticle-induced oxidative stress and toxicity[J].BioMed Research International, 2013,2013:942916;doi: 10.1155/2013/942916.
    [16]
    PARK E J, KIM H, KIM Y, et al.Repeated-dose toxicity attributed to aluminum nanoparticles following 28-day oral administration, particularly on gene expression in mouse brain[J]. Toxicological & Environmental Chemistry, 93 (2011) 120-133.
    [17]
    BERTHON G. Chemical speciation studies in relation to aluminium metabolism and toxicity[J]. Coordination Chemistry Reviews,1996, 149(1): 241-280.
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